pc runs slow and ISD error

My PC runs slow n takes years to shut down also i get an interactive services detection error every 20mins if i dnt view the msg n all

thanx

Logfile of Trend Micro HijackThis v2.0.4
Scan saved at 11:34:47 PM, on 6/3/2013
Platform: Windows 7 SP1 (WinNT 6.00.3505)
MSIE: Unable to get Internet Explorer version!
Boot mode: Normal

Running processes:
C:\Windows\Explorer.EXE
C:\Windows\system32\taskhost.exe
C:\Program Files\Avira\AntiVir Desktop\avgnt.exe
C:\Program Files\COMODO\COMODO Internet Security\cfp.exe
C:\Program Files\Realtek\Audio\HDA\RtHDVCpl.exe
C:\Program Files\IObit\Advanced SystemCare 6\ASCTray.exe
C:\Program Files\IObit\Advanced SystemCare 6\Suo10_SmartRAM.exe
C:\Windows\system32\taskeng.exe
C:\Program Files\IObit\Smart Defrag 2\SmartDefrag.exe
C:\Program Files\IObit\Advanced SystemCare 6\Monitor.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\AppData\Local\Google\Chrome\Application\chrome.exe
C:\Users\Acer\Desktop\Sillouttes\HijackThis.exe

R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = about:blank
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://home.gamesgofree.com/?utm_source=hpe&utm_medium=hp3
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant =
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,CustomizeSearch =
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Local Page =
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Local Page =
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyOverride = 127.0.0.1:9421;
R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
R3 - URLSearchHook: (no name) - {03EB0E9C-7A91-4381-A220-9B52B641CDB1} - (no file)
R3 - URLSearchHook: (no name) - {A3BC75A2-1F87-4686-AA43-5347D756017C} - (no file)
R3 - URLSearchHook: (no name) - {EF99BD32-C1FB-11D2-892F-0090271D4F88} - (no file)
O2 - BHO: HP Print Enhancer - {0347C33E-8762-4905-BF09-768834316C61} - C:\Program Files\HP\Digital Imaging\Smart Web Printing\hpswp_printenhancer.dll (disabled by BHODemon)
O2 - BHO: (no name) - {03EB0E9C-7A91-4381-A220-9B52B641CDB1} - (no file)
O2 - BHO: Adobe PDF Link Helper - {18DF081C-E8AD-4283-A596-FA578C2EBDC3} - C:\Program Files\Common Files\Adobe\Acrobat\ActiveX\AcroIEHelperShim.dll (disabled by BHODemon)
O2 - BHO: Spybot-S&D IE Protection - {53707962-6F74-2D53-2644-206D7942484F} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O2 - BHO: Java(tm) Plug-In SSV Helper - {761497BB-D6F0-462C-B6EB-D4DAF1D92D43} - C:\Program Files\Java\jre7\bin\ssv.dll
O2 - BHO: (no name) - {9030D464-4C02-4ABF-8ECC-5164760863C6} - (no file)
O2 - BHO: (no name) - {9FDDE16B-836F-4806-AB1F-1455CBEFF289} - (no file)
O2 - BHO: Advanced SystemCare Browser Protection - {BA0C978D-D909-49B6-AFE2-8BDE245DC7E6} - C:\PROGRA~1\IObit\ADVANC~2\BROWER~1\ASCPlugin_Protection.dll
O2 - BHO: Free Download Manager - {CC59E0F9-7E43-44FA-9FAA-8377850BF205} - C:\Program Files\Free Download Manager\iefdm2.dll
O2 - BHO: Java(tm) Plug-In 2 SSV Helper - {DBC80044-A445-435b-BC74-9C25C1C588A9} - C:\Program Files\Java\jre7\bin\jp2ssv.dll
O2 - BHO: (no name) - {FFFFFFFF-CF4E-4F2B-BDC2-0E72E116A856} - (no file)
O3 - Toolbar: (no name) - {CCC7A320-B3CA-4199-B1A6-9F516DD69829} - (no file)
O3 - Toolbar: (no name) - {03EB0E9C-7A91-4381-A220-9B52B641CDB1} - (no file)
O4 - HKLM\..\Run: [avgnt] "C:\Program Files\Avira\AntiVir Desktop\avgnt.exe" /min
O4 - HKLM\..\Run: [COMODO Internet Security] "C:\Program Files\COMODO\COMODO Internet Security\cfp.exe" -h
O4 - HKLM\..\Run: [RTHDVCPL] C:\Program Files\Realtek\Audio\HDA\RtHDVCpl.exe -s
O4 - HKLM\..\Run: [IObit Malware Fighter] "C:\Program Files\IObit\IObit Malware Fighter\IMF.exe" /autostart
O4 - HKCU\..\Run: [Advanced SystemCare 6] "C:\Program Files\IObit\Advanced SystemCare 6\ASCTray.exe" /AutoStart
O4 - HKCU\..\Run: [SmartRAM] "C:\Program Files\IObit\Advanced SystemCare 6\Suo10_SmartRAM.exe" /m
O4 - HKCU\..\Run: [uTorrent] "C:\Program Files\uTorrent\uTorrent.exe" /MINIMIZED
O4 - HKUS\S-1-5-19\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /autoRun (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-19\..\RunOnce: [mctadmin] C:\Windows\System32\mctadmin.exe (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-20\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /autoRun (User 'NETWORK SERVICE')
O4 - HKUS\S-1-5-20\..\RunOnce: [mctadmin] C:\Windows\System32\mctadmin.exe (User 'NETWORK SERVICE')
O8 - Extra context menu item: Add to Google Photos Screensa&ver - res://C:\Windows\system32\GPhotos.scr/200
O8 - Extra context menu item: Download all with Free Download Manager - file://C:\Program Files\Free Download Manager\dlall.htm
O8 - Extra context menu item: Download selected with Free Download Manager - file://C:\Program Files\Free Download Manager\dlselected.htm
O8 - Extra context menu item: Download video with Free Download Manager - file://C:\Program Files\Free Download Manager\dlfvideo.htm
O8 - Extra context menu item: Download with Free Download Manager - file://C:\Program Files\Free Download Manager\dllink.htm
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~1\Office12\EXCEL.EXE/3000
O9 - Extra button: (no name) - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O9 - Extra 'Tools' menuitem: Spybot - Search & Destroy Configuration - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O11 - Options group: [ACCELERATED_GRAPHICS] Accelerated graphics
O15 - Trusted Zone: *.clonewarsadventures.com
O15 - Trusted Zone: *.freerealms.com
O15 - Trusted Zone: *.soe.com
O15 - Trusted Zone: *.sony.com
O16 - DPF: {CAFEEFAC-0016-0000-0022-ABCDEFFEDCBA} (Java Plug-in 1.6.0_22) -
O18 - Protocol: skype4com - {FFC8B962-9B40-4DFF-9458-1830C7DD7F5D} - C:\PROGRA~1\COMMON~1\Skype\SKYPE4~1.DLL
O20 - AppInit_DLLs: c:\windows\system32\guard32.dll
O23 - Service: Advanced SystemCare Service 6 (AdvancedSystemCareService6) - IObit - C:\Program Files\IObit\Advanced SystemCare 6\ASCService.exe
O23 - Service: Avira Scheduler (AntiVirSchedulerService) - Avira Operations GmbH & Co. KG - C:\Program Files\Avira\AntiVir Desktop\sched.exe
O23 - Service: Avira Real-Time Protection (AntiVirService) - Avira Operations GmbH & Co. KG - C:\Program Files\Avira\AntiVir Desktop\avguard.exe
O23 - Service: COMODO Internet Security Helper Service (cmdagent) - COMODO - C:\Program Files\COMODO\COMODO Internet Security\cmdagent.exe
O23 - Service: Google Update Service (gupdate) (gupdate) - Google Inc. - C:\Program Files\Google\Update\GoogleUpdate.exe
O23 - Service: Google Update Service (gupdatem) (gupdatem) - Google Inc. - C:\Program Files\Google\Update\GoogleUpdate.exe
O23 - Service: Google Software Updater (gusvc) - Google - C:\Program Files\Google\Common\Google Updater\GoogleUpdaterService.exe
O23 - Service: IMF Service (IMFservice) - IObit - C:\Program Files\IObit\IObit Malware Fighter\IMFsrv.exe

--
End of file - 7748 bytes

Let's see, Avira, Comodo Internet Security, Iobit Malware Fighter, and Advanced System Care all running at the same time, it's a wonder it is able to even run slowly. You only need one Anti Virus program running and personally I would get rid of the Iobit and Advanced System Care. As far as Comodo and Avira go, make a choice and uninstall the other.