hi,
I work on 2 OS Vista & Win 7 and have installed the combo of Kaspersky & Advanced System Protector on Vista and Macfee & Advanced System Protector on Win 7.All 3 of them are good and the reason of using Advanced System Protector on both the OS is that it not only blocks the spyware b4 it can enter your system,will also clean the infections if any and it gives routine updates of the latest definitions and makes the browsing safe and is very easy to use.The On Execution Scanner & Alert Shields make it more efficient in the case of internet access. It isCompatible with Windows 2000, XP ,win 7and Vista (both 32 and 64 bit)
For me the Advanced System Protector is the Best Antimalware/antispyware
U can also give a try
free version of ASP is also available
http://www.systweak.com/AntiSpyware/Download/