Can't click on desktop icons PLEASE HELP!

I believe I got a virus. I can't click on desktop icons or even get Task manager to come up with CTRL-ALT-DEL.

Here's my HiJack This log

Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 08:06:26, on 10.03.2010
Platform: Windows XP SP3 (WinNT 5.01.2600)
MSIE: Internet Explorer v8.00 (8.00.6001.18702)
Boot mode: Safe mode with network support
Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\Explorer.EXE
C:\Programme\Internet Explorer\iexplore.exe
C:\Programme\Internet Explorer\iexplore.exe
C:\WINDOWS\system32\ctfmon.exe
C:\Programme\Internet Explorer\iexplore.exe
C:\WINDOWS\system32\igfxsrvc.exe
C:\Dokumente und Einstellungen\Dr. Wu\Lokale Einstellungen\Temporary Internet Files\Content.IE5\WR854PIB\HijackThis[1].exe
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.asus.com/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKCU\Software\Microsoft\Internet Connection Wizard,ShellNext = http://windowsupdate.microsoft.com/
O2 - BHO: AcroIEHlprObj Class - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - c:\Programme\Adobe\Acrobat 7.0\ActiveX\AcroIEHelper.dll
O2 - BHO: Sophos Web Content Scanner - {39EA7695-B3F2-4C44-A4BC-297ADA8FD235} - C:\Programme\Sophos\Sophos Anti-Virus\SophosBHO.dll
O2 - BHO: Norton Internet Security - {9ECB9560-04F9-4bbc-943D-298DDF1699E1} - c:\Programme\Gemeinsame Dateien\Symantec Shared\AdBlocking\NISShExt.dll
O2 - BHO: NAV Helper - {BDF3E430-B101-42AD-A544-FADC6B084872} - c:\Programme\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O3 - Toolbar: Norton Internet Security - {0B53EAC3-8D69-4b9e-9B19-A37C9A5676A7} - c:\Programme\Gemeinsame Dateien\Symantec Shared\AdBlocking\NISShExt.dll
O3 - Toolbar: Norton AntiVirus - {42CDD1BF-3FFB-4238-8AD1-7859DF00B1D6} - c:\Programme\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O4 - HKLM\..\Run: [HControl] C:\WINDOWS\ATK0100\HControl.exe
O4 - HKLM\..\Run: [igfxtray] C:\WINDOWS\system32\igfxtray.exe
O4 - HKLM\..\Run: [igfxhkcmd] C:\WINDOWS\system32\hkcmd.exe
O4 - HKLM\..\Run: [igfxpers] C:\WINDOWS\system32\igfxpers.exe
O4 - HKLM\..\Run: [SigmatelSysTrayApp] stsystra.exe
O4 - HKLM\..\Run: [Wireless Console 2] C:\Programme\Wireless Console 2\wcourier.exe
O4 - HKLM\..\Run: [ATKMEDIA] C:\Programme\ASUS\ATK Media\DMEDIA.EXE
O4 - HKLM\..\Run: [SynTPEnh] C:\Programme\Synaptics\SynTP\SynTPEnh.exe
O4 - HKLM\..\Run: [ABLKSR] C:\WINDOWS\ABLKSR\ABLKSR.exe
O4 - HKLM\..\Run: [ccApp] "c:\Programme\Gemeinsame Dateien\Symantec Shared\ccApp.exe"
O4 - HKLM\..\Run: [Power_Gear] C:\Programme\ASUS\Power4 Gear\BatteryLife.exe 1
O4 - HKLM\..\Run: [ACMON] C:\Programme\ASUS\Splendid\ACMON.exe
O4 - HKLM\..\Run: [IntelZeroConfig] "C:\Programme\Intel\Wireless\bin\ZCfgSvc.exe"
O4 - HKLM\..\Run: [IntelWireless] "C:\Programme\Intel\Wireless\Bin\ifrmewrk.exe" /tf Intel PROSet/Wireless
O4 - HKLM\..\Run: [EOUApp] "C:\Programme\Intel\Wireless\Bin\EOUWiz.exe"
O4 - HKLM\..\Run: [IMJPMIG8.1] "C:\WINDOWS\IME\imjp8_1\IMJPMIG.EXE" /Spoil /RemAdvDef /Migration32
O4 - HKLM\..\Run: [MSPY2002] C:\WINDOWS\system32\IME\PINTLGNT\ImScInst.exe /SYNC
O4 - HKLM\..\Run: [PHIME2002ASync] C:\WINDOWS\system32\IME\TINTLGNT\TINTSETP.EXE /SYNC
O4 - HKLM\..\Run: [PHIME2002A] C:\WINDOWS\system32\IME\TINTLGNT\TINTSETP.EXE /IMEName
O4 - HKLM\..\Run: [Tweak UI] RUNDLL32.EXE TWEAKUI.CPL,TweakMeUp
O4 - HKCU\..\Run: [ctfmon.exe] C:\WINDOWS\system32\ctfmon.exe
O4 - HKUS\S-1-5-19\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'LOKALER DIENST')
O4 - HKUS\S-1-5-20\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'NETZWERKDIENST')
O4 - HKUS\S-1-5-18\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'SYSTEM')
O4 - HKUS\.DEFAULT\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'Default user')
O4 - Global Startup: Sophos AutoUpdate Monitor.lnk = C:\Programme\Sophos\AutoUpdate\ALMon.exe
O8 - Extra context menu item: Download with Xilisoft YouTube Video Converter - D:\Eigene Musik\YouTube Video Converter\upod_link.HTM
O9 - Extra button: (no name) - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra 'Tools' menuitem: @xpsp3res.dll,-20001 - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Programme\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Programme\Messenger\msmsgs.exe
O14 - IERESET.INF: START_PAGE_URL=http://www.asus.com
O16 - DPF: {049A470D-F818-4E34-B14D-E4E237DADCF8} (CPlayFirstFashionDasControl Object) - http://games.bigfishgames.com/en_fashion-dash/online/fashiondashweb.1.0.0.21.cab
O16 - DPF: {055B4212-4C81-448E-AFA9-C3CA4AAE8F95} (CPlayFirstDairyDashWControl Object) - http://games.bigfishgames.com/en_dairy-dash-game/online/DairyDashWeb.1.0.0.15.cab
O16 - DPF: {21BB8360-F943-447E-98F3-3C22345375A7} (CPlayFirstChocolatierControl Object) - http://www.shockwave.com/content/chocolatier/sis/ChocolatierWeb.1.0.0.13.cab
O16 - DPF: {2D168880-539F-4967-BA11-F7C2862B9E1D} (CPlayFirstDiaperDashControl Object) - http://games.bigfishgames.com/en_diaper-dash/online/DiaperDashWeb.1.0.0.4.cab
O16 - DPF: {6C7CAD20-85AA-475A-AC0D-303C4A9A69CE} (CPlayFirstGreatChocoControl Object) - http://www.shockwave.com/content/greatchocolatechase/sis/greatchocolatechaseweb.1.0.0.12.cab
O16 - DPF: {74E4A24D-5224-4F05-8A41-99445E0FC22B} (GameHouse Games Player) - http://www.shockwave.com/content/deliciousteagarden/sis/gamehouseplayer.cab
O16 - DPF: {D40F5876-A494-4124-8161-82625BB28C06} (CPlayFirstChocolatieControl Object) - http://www.shockwave.com/content/chocolatier2/sis/Chocolatier2Web.1.0.0.10.cab
O20 - AppInit_DLLs: C:\PROGRA~1\Sophos\SOPHOS~1\SOPHOS~1.DLL
O23 - Service: Automatic LiveUpdate Scheduler - Symantec Corporation - C:\Programme\Symantec\LiveUpdate\ALUSchedulerSvc.exe
O23 - Service: Symantec Event Manager (ccEvtMgr) - Symantec Corporation - c:\Programme\Gemeinsame Dateien\Symantec Shared\ccEvtMgr.exe
O23 - Service: Symantec Network Proxy (ccProxy) - Symantec Corporation - c:\Programme\Gemeinsame Dateien\Symantec Shared\ccProxy.exe
O23 - Service: Symantec Password Validation (ccPwdSvc) - Symantec Corporation - c:\Programme\Gemeinsame Dateien\Symantec Shared\ccPwdSvc.exe
O23 - Service: Symantec Settings Manager (ccSetMgr) - Symantec Corporation - c:\Programme\Gemeinsame Dateien\Symantec Shared\ccSetMgr.exe
O23 - Service: Intel(R) PROSet/Wireless Event Log (EvtEng) - Intel Corporation - C:\Programme\Intel\Wireless\Bin\EvtEng.exe
O23 - Service: ISSvc (ISSVC) - Symantec Corporation - c:\Programme\Norton Internet Security\ISSVC.exe
O23 - Service: LiveUpdate - Symantec Corporation - C:\PROGRA~1\Symantec\LIVEUP~1\LUCOMS~1.EXE
O23 - Service: Norton AntiVirus Auto-Protect Service (navapsvc) - Symantec Corporation - c:\Programme\Norton Internet Security\Norton AntiVirus\navapsvc.exe
O23 - Service: Intel(R) PROSet/Wireless Registry Service (RegSrvc) - Intel Corporation - C:\Programme\Intel\Wireless\Bin\RegSrvc.exe
O23 - Service: Intel(R) PROSet/Wireless Service (S24EventMonitor) - Intel Corporation - C:\Programme\Intel\Wireless\Bin\S24EvMon.exe
O23 - Service: Sophos Anti-Virus Statusreporter (SAVAdminService) - Sophos Plc - C:\Programme\Sophos\Sophos Anti-Virus\SAVAdminService.exe
O23 - Service: SAVScan - Symantec Corporation - c:\Programme\Norton Internet Security\Norton AntiVirus\SAVScan.exe
O23 - Service: Sophos Anti-Virus (SAVService) - Sophos Plc - C:\Programme\Sophos\Sophos Anti-Virus\SavService.exe
O23 - Service: ScriptBlocking Service (SBService) - Symantec Corporation - C:\PROGRA~1\GEMEIN~1\SYMANT~1\SCRIPT~1\SBServ.exe
O23 - Service: Sophos AutoUpdate Service - Sophos Plc - C:\Programme\Sophos\AutoUpdate\ALsvc.exe
--
End of file - 8291 bytes

I will run Malwarebytes soon and report back. Also is it just me or does the Hijack This log look fairly normal? If so, could it be because I'm running in safe mode? I can't do a single thing in regular mode so I may not be able to get a HJ log with the virus completely loaded. What am I going to do?!

Go ahead with the Malwarebytes log.